Mechanism of racemization of amino acids by aspartate aminotransferase
نویسندگان
چکیده
منابع مشابه
Racemization of Meteoritic Amino Acids
Meteorites may have contributed amino acids to the prebiotic Earth, affecting the global ratio of right-handed to left-handed (D/ L) molecules. We calculate D/ L ratios for seven biological, α-hydrogen, protein amino acids over a variety of plausible parent body thermal histories, based on meteorite evidence and asteroid modeling. We show that amino acids in meteorites do not necessarily underg...
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Isoleucine, one of several amino acids isolated from a suite of welldated deep-sea cores, shows a progressive increase in the degree of racemization with the age of the sediment. Amino acids in sediments show an initial rate of racemization almost an order of magnitude faster than the rate observed for free amino acids at a comparable pH and temperature. The observed kinetics depend on a variet...
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1. The capacity ofvarious amino acids to convert the pyridoxal form ofaspartate aminotransferase into the pyridoxamine form has been investigated. 2. Glutamate has the highest converting capacity; aspartate, cx-aminopimelate, oc-aminoadipate and other amino acids follow. 3. The converting capacity of the various amino acids assayed is connected with their structural features. 4. A possible role...
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The ratios of d- versus l-amino acids can be used to infer the sources and composition of sedimentary organic matter. Such inferences, however, rely on knowing the rates at which amino acids in sedimentary organic matter racemize abiotically between the d- and the l-forms. Based on a heating experiment, we report kinetic parameters for racemization of aspartic acid, glutamic acid, serine, and a...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1992
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1992.tb16584.x